HARMONY

The Drug Rescue Platform.

FDA50 identifies exactly why a drug fails safety review. HARMONY generates the fix — a modified scaffold that clears the failing gate. No crystal structure. No bound pose. No bioactivity training data required.

Know the Gate. Fix the Scaffold.

See How It Works Run a Compound

A safety signal surfaces — in Phase 2, Phase 3, or after approval — and a program with a valid mechanism of action gets written off.
The biology worked. Only the scaffold carried the liability.

Every existing computational tool that could help needs something you don't have at that stage: a crystal structure, a bound pose, or years of SAR data. HARMONY needs none of them.

The Problem HARMONY Solves

$200–400M. Development cost stranded when a valid drug fails on safety alone.

The biology worked. Only the scaffold carried the liability. HARMONY was built to fix that.

96%

Overall accuracy across 28 pre-registered clinical cases

12/12

Physics-only predictions correct, plus 1 honest abstention

Protein safety panel spanning five liability classes

94%

Of clinically actionable variant-drug pairs are in-scope

The FDA50 Safety Panel

One panel. Every failure mode that ends a program.

FDA50 screens a compound's SMILES string against a 53-protein safety panel spanning five liability classes.

Cardiac

hERG & Ion Channel

The gate that ended Vioxx. HARMONY identified the failure and generated a scaffold that clears it — the same chemical class that replaced it on the market.

Hepatic / Metabolic

CYP Enzymes

Metabolic liabilities that turn a promising compound into a drug-drug interaction risk before it ever reaches trial.

CNS

Off-Target Binding

Unintended CNS receptor engagement is a common driver of late-stage safety signals. FDA50 flags it before synthesis, not after a trial arm closes.

The Platform

It generates the fix, not just the diagnosis.

HARMONY is built around three components, working together to diagnose a safety failure and generate a compound that clears it.

FDA50 Safety Panel

A 53-protein gate scan that identifies the exact protein and mechanism behind a safety failure, directly from a drug's SMILES string.

Generative Rescue Loop

Proposes a structurally modified analog engineered to clear the identified gate while preserving the original target engagement.

OMNIC Timestamp

A cryptographic timestamp applied the moment a rescue analog is generated, establishing a documented composition-of-matter priority date.

A Platform, Not a Single Fix

One system, applicable to any compound that fails on safety grounds, not a bet on a single molecule.

Latest · Moving Fast

New results, roughly every two weeks.

Validation · 2026

HARMONY MESH 3.0 achieves 96% accuracy across 28 pre-registered clinical cases. Every call time-stamped before the label was inspected.

2026

Pipeline · Jul 2026

Single scaffold shows confirmed activity across four consecutive cancer pathway targets — a combination no approved drug currently covers.

July 2026

IP · Jul 2026

7 USPTO provisional patents confirmed.